A programme for ageing research with worms

Luyten W, and 19 other authors including AML. 2016. Ageing with elegans: a research proposal to map healthspan pathways. Biogerontology  7: 71–782

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Posted in ageing, metabolism, peer-reviewed articles, Uncategorized

State-of-the-art-metabolomics for worms

Geier FM, Fuchs S, Valbuena G, Leroi AMBundy JG. 2013. Profiling the metabolic signature of senescence. Methods in Molecular Biology 965:355-37

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Posted in ageing, metabolism, peer-reviewed articles

Methods to age worms by

Davies SK, Leroi AM, Bundy JG. 2012. Fluorodeoxyuridine affects the identification of metabolic responses to daf-2 status in Caenorhabditis elegans. Mechanisms of Ageing and Development. 133: 46-49

 

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Posted in ageing, metabolism, peer-reviewed articles

A microfluidic worm-sorter

Casadevall i Solvas X, Geier FM, Leroi AM, Bundy JG, Edel JB, deMello, AJ 2011 High-throughput age synchronisation of Caenorhabditis elegans. Chem Comm DOI: 101039/c1cc14076k

 

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Posted in ageing, metabolism, peer-reviewed articles

Metabolomics of ageing in worms

Fuchs S, Bundy JG, Davies SK, Bundy J, Leroi AM. 2010. A metabolic signature of long life in Caenorhabditis elegans. BMC Biology 8: 2

 

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Posted in ageing, metabolism, peer-reviewed articles

Antagonistic pleiotropy and ageing

Leroi AM et al. 2005. What is the evidence for the existence of individual genes with antagonistic pleiotropic effects? Mechanisms of Ageing and Development. 126:421-9

 

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Posted in ageing, peer-reviewed articles

Mutants – book

Leroi AM. 2003. Mutants: on the form, variety and errors of the the human body

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Posted in ageing, books, general evolution, history of science, mutants & variants

Life-history trade-off QTLs in worms

Knight CG, Azevedo RBR, Leroi AM. 2001. Testing life-history pleiotropy in Caenorhabditis elegans. Evolution 55:1795-1804

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Posted in ageing, peer-reviewed articles

Rethinking life-history trade-offs

Leroi, AM. 2001. Molecular signals v the loi de balancement. Trends in Ecology and Evolution 16:24-29

 

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Posted in ageing, general evolution, peer-reviewed articles

Food, sex, life-history

Chippindale AK, Leroi AM, H Saing, Borash D and Rose MR. 1997. Phenotypic plasticity and selection in Drosophila life-history evolution. 2. Mating status, nutrition and the cost of reproduction. Journal of Evolutionary Biology 10:269-293

 

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Posted in ageing, peer-reviewed articles

Phenotypic and genetic trade-offs

Leroi AM, Kim SB and Rose MR. 1994. The evolution of phenotypic life-history trade-offs: an experimental study using Drosophila melanogasterAmerican Naturalist 144:661–676

 

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Posted in ageing, general evolution, peer-reviewed articles

Evolutionary stability of life-history genetic correlations

Leroi AM, Chen WR and Rose MR. 1994. Long term laboratory evolution of a life-history trade-off in Drosophila melanogaster. 2. Stability of genetic correlations. Evolution 48:1258-1268

 

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Posted in ageing, general evolution, peer-reviewed articles

Evolutionary instability of life-history trade-offs

Leroi AM, Chippindale AK, and Rose MR. 1994. Long term laboratory evolution of a life-history trade-off in Drosophila melanogaster. 1. The role of genotype x environment interaction Evolution 48: 1244-1257

 

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Posted in ageing, peer-reviewed articles

Dietary restriction in Drosophila

Chippindale AK, Leroi AM, Kim SB, Rose MR. 1993. Phenotypic plasticity and selection in Drosophila life-history evolution. 1. Nutrition and the cost of reproduction. Journal of Evolutionary Biology 6:17-93

 

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Posted in ageing, peer-reviewed articles