The balloon hypothesis

Swire J, Fuchs S, Bundy JG, Leroi AM. 2009. The cellular geometry of growth drives the amino acid economy of Caenorhabditis elegans. Proc Biol Sci B. 276:2747-54

 

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Posted in growth, metabolism, peer-reviewed articles

Diet regulates ploidy and growth in worms

Tain LS, Lozano E, Saez AG, Leroi AM. 2008. Dietary regulation of body size via hypodermal polyploidization in C elegans BMC Developmental Biology 8:28

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Posted in growth, peer-reviewed articles

Ploidy drives growth in worms

Lozano E, Saez AG, Flemming AJ, Cunha A, Leroi AM. 2006. Regulation of growth by ploidy in Caenorhabditis elegans. Current Biology 7:493-8

 

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Posted in growth, peer-reviewed articles

Human mutants – tv series

Human Mutants. 2003.

TigerAspect for Channel 4 / Discovery USA (Presenter, Writer)

Directors:  Philip Smith, Damon Thomas

3 x 60

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Posted in growth, history of science, mutants & variants, tv & radio

Mutational constraints on growth

Azevedo RB, Keightley PD, Lauren-Maatta C, Vassilieva LL, Lynch M, Leroi AM. 2002. Spontaneous mutational variation for body size in Caenorhabditis elegans Genetics 162:755-65

 

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Posted in general evolution, growth, peer-reviewed articles

Gonads regulate growth

Patel, M, CG Knight, C Karageorghi, AM Leroi. 2002. Evolution of germline signals that control growth and ageing in nematodes. Proceedings of the National Academy of Sciences, USA 99: 769-74

 

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Posted in growth, peer-reviewed articles

Collagens and regulation of growth in worms

Nystrom J, Shen ZZ, Aili M, Flemming AJ, Leroi AM, Tuck S. 2002. Increased or decreased levels of Caenorhabditis elegans lon-3, a gene encoding a collagen, cause reciprocal changes in body length. Genetics 161: 83-97

 

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Posted in growth, peer-reviewed articles

Molecular regulation of ploidy in worms

Morita K, Flemming AJ, Sugihara Y, Mochii M, Suzuki Y, Yoshida S, Wood WB, Kohara Y, Leroi AM, Ueno N. 2002. A Caenorhabditis elegans TGF-beta, DBL-1, controls the expression of LON-1, a PR-related protein, that regulates polyploidization and body length. Embo J. 21:1063-73

 

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Posted in growth, peer-reviewed articles

Why worms moult

Knight C, Patel MN, Azevedo RBR, Flemming A, Leroi AM. 2001. A novel mode of ecdysozoan growth in Caenorhabditis elegans. Evolution & Development 4:16-27

 

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Posted in growth, peer-reviewed articles

The virtues of being short

Leroi AM. 2001. Could the future be “survival of the shortest?” The Independent 03.04.01

Posted in growth, journalism

Ploidy and growth in worms

Flemming AJ, Shen ZZ, Cunha A, Emmons SW, Leroi AM. 2000. Somatic polyploidization and cellular proliferation drive body size evolution in nematodes. Proceedings of the National Academy of Sciences USA 97: 5285-5290

 

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Posted in growth, peer-reviewed articles