A programme for ageing research with worms

Luyten W, and 19 other authors including AML. 2016. Ageing with elegans: a research proposal to map healthspan pathways. Biogerontology  7: 71–782

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Posted in ageing, metabolism, peer-reviewed articles, Uncategorized

Diversity in Argentinian killifishes

Helmstetter AJ, Papadopulos AST, Igea J, Van Dooren TJM,  Leroi AM. Savolainen V. 2016. Viviparity stimulates diversification in an order of fish.  Nature Communications 7: 11271

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Posted in general evolution, peer-reviewed articles, Uncategorized

Mutational metabolomics

Davies SK, Leroi AM, Burt A, Bundy JG, Baer CF. 2016. The mutational structure of metabolism in Caenorhabditis elegans.  Evolution 70: 1558-564

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Posted in general evolution, metabolism, mutants & variants, peer-reviewed articles, Uncategorized

Pop music revolutions

popMauch M, MacCullum RM, Levy M, Leroi AM. 2015. The evolution of popular music: USA 1960–2010  R. Soc. open sci. 2: 150081.

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Posted in evolution of culture, general evolution, peer-reviewed articles

State-of-the-art-metabolomics for worms

Geier FM, Fuchs S, Valbuena G, Leroi AMBundy JG. 2013. Profiling the metabolic signature of senescence. Methods in Molecular Biology 965:355-37

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Posted in ageing, metabolism, peer-reviewed articles

Darwinian evolution of music

MacCallum RM, Mauch M, Burt A, Leroi, AM. 2012. Evolution of music by public choice, Proceedings of the National Academy of Sciences, USA 109:12081–12086

 

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Posted in evolution of culture, peer-reviewed articles

Methods to age worms by

Davies SK, Leroi AM, Bundy JG. 2012. Fluorodeoxyuridine affects the identification of metabolic responses to daf-2 status in Caenorhabditis elegans. Mechanisms of Ageing and Development. 133: 46-49

 

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Posted in ageing, metabolism, peer-reviewed articles

How dog transmissible cancers stay alive

Rebbeck CA, Leroi AM, Burt A. 2011. Mitochondrial capture by a transmissible cancer. Science. 311:1095-9203

 

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Posted in general evolution, peer-reviewed articles

A microfluidic worm-sorter

Casadevall i Solvas X, Geier FM, Leroi AM, Bundy JG, Edel JB, deMello, AJ 2011 High-throughput age synchronisation of Caenorhabditis elegans. Chem Comm DOI: 101039/c1cc14076k

 

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Posted in ageing, metabolism, peer-reviewed articles

Metabolomic methods

Geier FM, Want EJ, Leroi AM, Bundy JG. 2011. Cross-Platform Comparison of Caenorhabditis elegans. Tissue Extraction Strategies for Comprehensive Metabolome Coverage. Anal Chem. 83:3730-3736

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Posted in metabolism, peer-reviewed articles

Metabolomics of ageing in worms

Fuchs S, Bundy JG, Davies SK, Bundy J, Leroi AM. 2010. A metabolic signature of long life in Caenorhabditis elegans. BMC Biology 8: 2

 

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Posted in ageing, metabolism, peer-reviewed articles

Chromosome painting in transmissible cancers in dogs

Thomas R, Rebbeck C, Leroi AM, Burt, A. 2009. Extensive conservation of genomic imbalances incanine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis. Chromosome Research 17: 927-934

 

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Posted in general evolution, peer-reviewed articles

Origin of transmissible cancers in dogs

Rebbeck CA, Thomas R, Breen M, Leroi AM, Burt A. 2009. Origins and evolution of a transmissible cancer. Evolution 63: 2340-2349

 

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Posted in general evolution, peer-reviewed articles

The balloon hypothesis

Swire J, Fuchs S, Bundy JG, Leroi AM. 2009. The cellular geometry of growth drives the amino acid economy of Caenorhabditis elegans. Proc Biol Sci B. 276:2747-54

 

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Posted in growth, metabolism, peer-reviewed articles

Aristotle on life-history

Leroi AM. 2009. Function and Constraint in Aristotle and Evolutionary Theory in S Föllinger and W Kullmann Aristotle’s Conception of Life, Bamberg

 

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Posted in general evolution, history of science, peer-reviewed articles

Neo-cantometrics

Leroi AM,  Swire J. 2007. The Recovery of the Past. World of Music 48 101-118

 

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Posted in evolution of culture, history of science, peer-reviewed articles

Diet regulates ploidy and growth in worms

Tain LS, Lozano E, Saez AG, Leroi AM. 2008. Dietary regulation of body size via hypodermal polyploidization in C elegans BMC Developmental Biology 8:28

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Posted in growth, peer-reviewed articles

Ploidy drives growth in worms

Lozano E, Saez AG, Flemming AJ, Cunha A, Leroi AM. 2006. Regulation of growth by ploidy in Caenorhabditis elegans. Current Biology 7:493-8

 

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Posted in growth, peer-reviewed articles

Evolution of cell lineages

Azevedo, RBR, R Lohaus, V Braun M Gumbel, M Umamasheshewar, V Braun, P Agapow, G Borgonie, HP Meinzer, and AM Leroi. 2005. The simplicity of Metazoan cell lineages. Nature 433: 152-156

 

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Posted in general evolution, peer-reviewed articles

Antagonistic pleiotropy and ageing

Leroi AM et al. 2005. What is the evidence for the existence of individual genes with antagonistic pleiotropic effects? Mechanisms of Ageing and Development. 126:421-9

 

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Posted in ageing, peer-reviewed articles

An anecephalic infant mummy from Egypt

Geoffroy’s mummy

Dasen V, Leroi AM. 2004. Homme ou bête? Le dieu caché de l’anencéphale d’Hermopolis in A Carol (ed) Le monstre humain : imaginaire et societe UP Paris

Posted in history of science, mutants & variants, peer-reviewed articles

Cancer selection

Leroi, A. M. V. Koufopanou, A. Burt. 2003.  Cancer Selection. Nature Reviews Cancer 3:226-31.

 

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Posted in general evolution, peer-reviewed articles

Mutational constraints on growth

Azevedo RB, Keightley PD, Lauren-Maatta C, Vassilieva LL, Lynch M, Leroi AM. 2002. Spontaneous mutational variation for body size in Caenorhabditis elegans Genetics 162:755-65

 

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Posted in general evolution, growth, peer-reviewed articles

Gonads regulate growth

Patel, M, CG Knight, C Karageorghi, AM Leroi. 2002. Evolution of germline signals that control growth and ageing in nematodes. Proceedings of the National Academy of Sciences, USA 99: 769-74

 

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Posted in growth, peer-reviewed articles

Collagens and regulation of growth in worms

Nystrom J, Shen ZZ, Aili M, Flemming AJ, Leroi AM, Tuck S. 2002. Increased or decreased levels of Caenorhabditis elegans lon-3, a gene encoding a collagen, cause reciprocal changes in body length. Genetics 161: 83-97

 

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Posted in growth, peer-reviewed articles

Evo-devo surveyed

Leroi AM. 2002. Evolution of Development in M Pagel et al (eds) Encylopedia of Evolution, Oxford University Press

 

Posted in general evolution, history of science, peer-reviewed articles

Molecular regulation of ploidy in worms

Morita K, Flemming AJ, Sugihara Y, Mochii M, Suzuki Y, Yoshida S, Wood WB, Kohara Y, Leroi AM, Ueno N. 2002. A Caenorhabditis elegans TGF-beta, DBL-1, controls the expression of LON-1, a PR-related protein, that regulates polyploidization and body length. Embo J. 21:1063-73

 

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Posted in growth, peer-reviewed articles

Why worms moult

Knight C, Patel MN, Azevedo RBR, Flemming A, Leroi AM. 2001. A novel mode of ecdysozoan growth in Caenorhabditis elegans. Evolution & Development 4:16-27

 

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Posted in growth, peer-reviewed articles

Life-history trade-off QTLs in worms

Knight CG, Azevedo RBR, Leroi AM. 2001. Testing life-history pleiotropy in Caenorhabditis elegans. Evolution 55:1795-1804

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Posted in ageing, peer-reviewed articles

Patterns of cell number variability

Azevedo, RBR, Leroi AM. 2001. A power law for cells. Proceedings of the National Academy of Science USA 98:5699-5704

 

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Posted in general evolution, peer-reviewed articles

Rethinking life-history trade-offs

Leroi, AM. 2001. Molecular signals v the loi de balancement. Trends in Ecology and Evolution 16:24-29

 

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Posted in ageing, general evolution, peer-reviewed articles

Micro v. macroevolution

Leroi AM. 2000. The scale independence of evolution. Evolution & Development 2: 67-77

 

 

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Posted in general evolution, peer-reviewed articles

Ploidy and growth in worms

Flemming AJ, Shen ZZ, Cunha A, Emmons SW, Leroi AM. 2000. Somatic polyploidization and cellular proliferation drive body size evolution in nematodes. Proceedings of the National Academy of Sciences USA 97: 5285-5290

 

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Posted in growth, peer-reviewed articles

Nematodes are not eutelic

Cunha A, RB Azevedo, Emmons S, Leroi AM. 1999. Variable cell numbers in nematodes. Nature 402:253

Azevedo, RBR, Cunha, A, Emmons, SW, Leroi AM. The demise of the Platonic worm. Nematology. 2. 71-79

 

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Posted in general evolution, peer-reviewed articles

Nematode physiology

Leroi AM and Jones J. 1998. Development of Nematodes in R Perry and D J Wright (eds) Physiology and Biochemistry of Free-Living and Plant-Parasitic Nematodes p. 155-175

 

Posted in general evolution, peer-reviewed articles

Food, sex, life-history

Chippindale AK, Leroi AM, H Saing, Borash D and Rose MR. 1997. Phenotypic plasticity and selection in Drosophila life-history evolution. 2. Mating status, nutrition and the cost of reproduction. Journal of Evolutionary Biology 10:269-293

 

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Posted in ageing, peer-reviewed articles

Thermal adaptation

Leroi AM, Lenski RE and Bennett AF. 1995. Evolution of Thermal adaptation III Phenotypic acclimation and genetic adaptation of Escherichia coli to a temporally variable environment. Evolution 48:1222-1229

 

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Posted in general evolution, peer-reviewed articles

Phenotypic and genetic trade-offs

Leroi AM, Kim SB and Rose MR. 1994. The evolution of phenotypic life-history trade-offs: an experimental study using Drosophila melanogasterAmerican Naturalist 144:661–676

 

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Posted in ageing, general evolution, peer-reviewed articles

Evolutionary stability of life-history genetic correlations

Leroi AM, Chen WR and Rose MR. 1994. Long term laboratory evolution of a life-history trade-off in Drosophila melanogaster. 2. Stability of genetic correlations. Evolution 48:1258-1268

 

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Posted in ageing, general evolution, peer-reviewed articles

Evolutionary instability of life-history trade-offs

Leroi AM, Chippindale AK, and Rose MR. 1994. Long term laboratory evolution of a life-history trade-off in Drosophila melanogaster. 1. The role of genotype x environment interaction Evolution 48: 1244-1257

 

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Posted in ageing, peer-reviewed articles

The beneficial acclimation hypothesis

Leroi AM, Bennett AF, Lenski RE. 1994. Heat acclimation increases high temperature survival in Escherichia coli. Proceedings of the National Academy of Sciences, USA 91:1917-1921

 

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Posted in peer-reviewed articles

Critique of the comparative method

Leroi AM, Rose MR, Lauder GV. 1994. Can the comparative method reveal adaptation? American Naturalist 143:381-402

 

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Posted in general evolution, peer-reviewed articles

Adapation & history

Lauder GV, Leroi AM, Rose MR. 1993. Adaptation and History. Trends in Ecology & Evolution 8: 294-297

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Posted in general evolution, peer-reviewed articles

Dietary restriction in Drosophila

Chippindale AK, Leroi AM, Kim SB, Rose MR. 1993. Phenotypic plasticity and selection in Drosophila life-history evolution. 1. Nutrition and the cost of reproduction. Journal of Evolutionary Biology 6:17-93

 

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Posted in ageing, peer-reviewed articles